Once the molecule file is fully loaded, the image at right will become live. At that time the "activate 3-D" icon will disappear.

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Simulation with and without the sickle cell mutation

In the previous slide, the sickle cell gene mutation that causes glutamic acid to be replaced with valine was shown. A simulation of two hemoglobin proteins with and without this mutation have been run to show how the sickle cell mutated glutamate "sticks" the two hemoglobin tetramers together so they can form long strands. The simulations were run for 175 ns (175*10^-9 s) - an exceedingly short time, but long enough to see the difference caused by the mutation.

The button "With Sickle Cell Mutation" appears below. Click it to see how the valine in position 6 keeps the two hemoglobin tetramers together over the course of the simulation.

With Sickle Cell Mutation

Animation

Mode:

The button "Without Sickle Cell Mutation" appears below. Click it to see how the two hemoglobin tetramers drift apart without the mutation, i.e., in their native state due to the random fluctuations always present at the molecular level.

Without Sickle Cell Mutation

Animation

Mode:

Using directory /Users/treyscheiper/Hemoglobin/HemoglobinSlide4
  adding support.js
  ...jmolApplet0
      ...adding With_Sickle_Cell_Mutation.png
      ...copying
/Users/treyscheiper/JC/HEMO/simulated/hemoglobin-E6V.pdb
         to
      ...compressing large data file to
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-E6V.pdb.gz
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-E6V.pdb.gz
      ...copying
/Users/treyscheiper/JC/HEMO/simulated/hemoglobin-E6V-175ns.dcd
         to
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-E6V-175ns.dcd
      ...adding With_Sickle_Cell_Mutation.spt
  ...jmolApplet1
      ...adding Without_Sickle_Cell_Mutation.png
      ...copying
/Users/treyscheiper/JC/HEMO/simulated/hemoglobin-WT.pdb
         to
      ...compressing large data file to
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-WT.pdb.gz
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-WT.pdb.gz
      ...copying
/Users/treyscheiper/JC/HEMO/simulated/hemoglobin-WT-175ns.dcd
         to
/Users/treyscheiper/Hemoglobin/HemoglobinSlide4/hemoglobin-WT-175ns.dcd
      ...adding Without_Sickle_Cell_Mutation.spt
  adding JmolAnimationCntrl.js
  adding lastButton.png
  adding playButton.png
  adding playLoopButton.png
  adding playOnceButton.png
  adding playPalindromeButton.png
  adding prevButton.png
  adding pauseButton.png
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  adding firstButton.png